Sinoway Industrial Co., Ltd

Date: 16th August 2016
Diosmin Hesperidin 90:10 powder
Sinoway Industrial Co.,Ltd is a famous China diosmin manufacturer and supplier, welcome to buy GMP and EP diosmin from us and check the price with us.Basic information ofDiosminNameDiosminCAS520-27-4EINECS208-289-7Molecular FormulaC28H32O15Molecular Weight609QualityStandardEP8.0Package Size25kg/drumBrief IntroductionGreyish-yellow or light yellow hygroscopic powder. Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.Use of Diosmin:Increasing Capillary toughness, lowing CholesterolTreating ?Cardiovascular diseaseAnti-virus and anti-inflammatoryTreating diseases such as hypertension and heart attackCOA ofDiosmin:Nature of TestSpecificationsTest ResultsCHARACTERS??- AppearanceGreyish-yellow or light yellow hygroscopic powder.Light yellow hygroscopic powder.- SolubilityPractically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in alcohol. It dissolves in dilute solutions of alkali hydroxides.ConformsIDENTIFICATION??A. Infrared absorption spectrophotometry (2.2.24)Comparison: diosmin CRSConformsB. Examine the chromatograms obtained in the AssayThe principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a).ConformsTESTS??- Iodine (2.2.36) & (2.5.10)? 0.1%< 0.1 %- Related substances (HPLC) (2.2.29)??-- impurity A: acetoisovanillone? 1.0 %0.07 %-- impurity B: hesperidin? 5.0 %1.1 %-- impurity C: isorhoifin? 3.0 %0.79 %-- impurity E: linarin? 3.0 %0.84 %-- impurity F: diosmetin? 3.0 %0.81 %-- any other impurity? 1.0 %<1.0%-- total of other impurities and impurity A? 1.0 %0.65 %-- total? 10.0 %4.5 %- Heavy metals (2.4.8)? 20 ppm< 20 ppm- Water (2.5.12)? 6.0 %3.5 %- Sulphated ash (2.4.14)? 0.2 %0.12 %ASSAY(HPLC), anhydrous substance (2.2.29)90.0%-102.0%95.3 %PARTTICLE SIZE DISTRIBUTION??- Particle size (by Laser Granulometry)100% ? 10 microns100% < 10 micronsRESIDUAL SOLVENTS (2.4.24) & (5.4)??- Methanol? 3000 ppm23 ppm- Ethanol? 5000 ppm0 ppm- Pyridine? 200 ppm80 ppmMICROBIOLOGICAL TESTS (2.6.12) & (2.6.13)??- Total Plate Count< 103 / g< 102 / g- Yeasts and Molds< 102 / g< 10 / g- SalmonellaNegative in 1 gNegative in 1 g- E. ColiformNegative in 1 gNegative in 1 gCONCLUSION: THE TEST RESULTS CONFORM TO Ph.Eur. 8.0.STORAGE CONDITIONS/TEMPERATURE: ROOM TEMPERATURE, PROTECT FROM LIGHT, AIR TIGHT.?For more details, pls. contact with me .?Ms. Denise LaiInternational Trade Dept.Sinoway Industrial Co.,Ltd? (established in 1987, ISO9001:2008 and SGS certificated)=============================Tel:0086 592 5887167Fax:0086 592 5854960Skype: sinoway-dlE-Mail: 0086 13459239406Web site: or
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