Sinoway Industrial Co., Ltd

Date: 16th August 2016
Ritonavir CAS:155213-67-5
1.??? Product Information?Product Name: Ritonavir Chemical Name: 1,3-thiazol-5-ylmethyl n-[(2s,3s,5r)-3-hydroxy-5-[[(2s)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenyl-hexan-2-yl]carbamateCas No.: 155213-67-5Molecular Formula: C37H48N6O5S2? Molecular Weight:? 720.96? 2. UsesThe main usage Ritonavir is to treat patients with human immunodeficiency virus (HIV), specifically Type 1, the more dangerous and prevalent type of HIV. Usually, Ritonavir and Lopinavir are combined in a tablet or in a liquid solution to make the treatment more effective. Basically, lopinavir and ritonavir act as an antivirus, preventing and reducing the production of HIV virus in the body. Patients should be informed that lopinavir and ritonavir are not used as a cure for HIV; rather, they are only used to treat and manage the condition. The combined drugs also do not prevent the virus from being transmitted from one person to another.4. SpecificationITEMSSPECIFICATIONS ? ?USP?APPEARANCEWHITE TO ALMOST ? WHITE POWDERSOLUBILITYFREELY SOLUBLE IN ? METHANOL AND IN METHYLENE CHLORIDE; VERY SLIGHTLY SOLUBLE IN ACETONITRILE; ? PRACTICALLY INSOLUBLE IN WATERIDENTIFICATIONA)??? ? BY IR THE INFRA RED ABSORPTION SPECTRUM OF ? THE SAMPLE IS CONCORDANT WITH THAT OF A SIMILAR PREPARATION OF RITONAVIR ? WORKING STANDARD/USP RS.B)??? ? BY HPLC: THE RETENTION TIME OF THE MAJOR ? PEAK IN THE CHROMATOGRAM OF THE ASSAY PREPARATION CORRESPONDS TO THAT IN THE ? CHROMATOGRAM OF THE STANDARD PREPARATION AS OBTAINED IN THE ASSAY. C)??? ? X-RAY DIFFRACTION: THE X-RAY DIFFRACTION ? PATTERN CONFORMS TO THAT OF USP RITONAVIR RS.HEAVY METALSNMT 0.002%WATER NMT 0.5%RESIDUE ON IGNITIONNOT MORE THAN 0.1%RELATED COMPOUNDSIMPURITY A + B?0.10%IMPURITY C?0.10%IMPURITY D?0.10%IMPURITY E?0.15%IMPURITY F?0.10%IMPURITY G?0.10%IMPURITY H?0.10%IMPURITY I?0.10%IMPURITY J+K?0.10%IMPURITY L?0.10%IMPURITY M?0.10%IMPURITY N?0.10%IMPURITY O?0.15%IMPURITY P?0.10%IMPURITY Q?0.10%IMPURITY R?0.10%IMPURITY S?0.10%IMPURITY T?0.15%IMPURITY U?0.10%ANY UNSPECIFIED? IMPURITY ?0.10%TOTAL IMPUTITIES ?0.60%ASSSAY? 98.0% TO 102.0% ON ANHYDROUS BASISRESIDUAL SOLVENTSETHYL ACETATE: NMT 0.5%TETRAHYDROFURAN :NMT 0.05% N-HEPTANE:NMT 0.15%?5. Specifications Fast Delivery ? Professional Manufacturer ? ISO, USP standard Good Quality and reasonable price
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